螺内酯，Spironolactone；97.0-103.0%

图片 螺内酯，Spironolactone；97.0-103.0%
别名：4-孕烷-21-油酸-17α-醇-3-酮-7α-硫醇γ-内酯7-乙酸盐, 7α-(乙酰硫基)-17α-羟基-3-氧杂戊烯-4-烯-21-羧酸γ-内酯；7α-(乙酰硫基)-17α-羟基-3-氧杂戊烯-4-烯-21-羧酸γ-内酯, 4-孕烷-21-油酸-17α-醇-3-酮-7α-硫醇γ-内酯7-乙酸盐；4-Pregnen-21-oic acid-17α-ol-3-one-7α-thiol γ-lactone 7-acetate, 7α-(Acetylthio)-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone

Empirical Formula (Hill Notation): C24H32O4S CAS号: 52-01-7 分子量: 416.57 EC 号: 200-133-6 MDL编号: MFCD00082250 PubChem化学物质编号: 24277736 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: S3378
CAS号: 52-01-7
MDL号: MFCD00082250
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¥755.00

说明

应用

Spironolactone was added to rat diet to study the effect of long-term spironolactone use on renal function.[1][2]
 

生化/生理作用

Spironolactone reduces aldosterone-induced potassium/magnesium loss and myocardial fibrosis.[3] It reduces hypertension,[4] improves the endothelial function and reduces the overall morbidity and mortality in patients with chronic heart failure.[5] Spironolactone improves nitric oxide bioactivity and vascular endothelial vasodilator dysfunction.[3]
螺内酯是竞争性醛固酮受体拮抗剂。 用作保钾利尿剂。
 

特点和优势

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

制备说明

Spironolactone yields clear, faint yellow solution in chloroform at 50 mg/ml.
 
 

属性

质量水平

200

检测方案

97.0-103.0%

mp

207-208 °C (lit.)

溶解性

chloroform: complete 50 mg/ml, clear, faintly yellow

创始人

Pfizer

SMILES string

CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]45CCC(=O)O5)[C@H]13

InChI

1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1

InChI key

LXMSZDCAJNLERA-ZHYRCANASA-N

Gene Information

human ... HSD17B1(3292) , NR3C2(4306)
rat ... Ar(24208)

 

安全信息

象形图

Health hazard
GHS08

警示用语：

Danger

危险分类

Carc. 2 - Repr. 1B - STOT RE 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

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储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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