蜂毒肽素，Melittin；>97% (HPLC)

图片 蜂毒肽素，Melittin；>97% (HPLC)
别名：Melittin； 经验公式（希尔记法）: C131H229N39O31 CAS号: 37231-28-0 分子量: 2846.46
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: 444605
CAS号: 37231-28-0
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说明

A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner.

一般描述

A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner, activates phospholipase A2, and inhibits protein kinase C (IC50 = 5-7 µM) by binding to the catalytic domain in a Mg2+-ATP sensitive manner. A stimulator of Giα and G11α activity that is reported to inhibit adenylate cyclase activity in synaptic membranes. Has also been used for affinity purification of several Ca2+-binding proteins. Activates Giα-1 and G11α activities and inhibits Gs activity.
A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner. A stimulator of Giα and G11α activity that is reported to inhibit adenylate cyclase activity in synaptic membranes. Activates phospholipase A2 and inhibits protein kinase C (IC50 = 5-7 µM) by binding to the catalytic domain in a Mg2+-ATP sensitive manner. Has also been used for affinity purification of several Ca2+-binding proteins.

生化/生理作用

Cell permeable: no
Product does not compete with ATP.
Reversible: no
Target IC50: 5-7 µM 5-7 µM for activating phospholipase A2 and inhibits protein kinase C

包装

Yes

警告

Toxicity: Standard Handling (A)

序列

H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH₂

其他说明

Fukushima, N., et al. 1998. Peptides19, 811.
Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425.
Baudier, J., et al. 1987. Biochemistry26, 2886.
Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun.133, 256.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
 
 

属性

质量水平

100

检测方案

>97% (HPLC)

形式

lyophilized

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

溶解性

water: 1 mg/mL

运输

ambient

储存温度

−20°C

InChI

1S/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,190)(H,169,200)(H4,139,140,143)(H4,141,142,144)

InChI key

VDXZNPDIRNWWCW-UHFFFAOYSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 30 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 30
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