芴甲氧羰酰-色氨酸,Fmoc-Trp(Boc)-OH;Novabiochem®, ≥98%

别名:Nα-芴甲氧羰基-N(in)-叔丁氧羰基-L-色氨酸;N(in)-Boc-Nα-Fmoc-L-色氨酸;Nα-Fmoc-N(in)-Boc-L-tryptophan, N(in)-Boc-Nα-Fmoc-L-tryptophan

Empirical Formula (Hill Notation): C31H30N2O6 CAS号: 143824-78-6 分子量: 526.58 MDL编号: MFCD00153366
货号(SKU): 8.52050
CAS号: 143824-78-6
MDL号: MFCD00153366
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¥1,590.66

说明

一般描述

High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities.
The use of this N-in-Boc protected derivative overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1,2,3] and sulfonation [1,4,5,6,7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide.

Associated Protocols and Technical Articles
Fmoc-amino acids for Peptide Production
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

[1] P. White in ′Peptides, Chemistry & Biology, Proc. 12th American Peptide Symposium′, J. A. Smith & J. E. Rivier (Eds), ESCOM, Leiden, 1992, pp. 537.
[2] B. Riniker, et al. (1993) Tetrahedron, 49, 9307.
[3] T. Johnson, et al. (1993) J. Chem. Soc., Chem. Commun., 369.
[4] H. Choi, et al. (1993) Int. J. Peptide Protein Res.42, 58.
[5] C. G. Fields, et al. (1993) Tetrahedron Lett.34, 6661.
[6] T. Lescrinier, et al. (1995) Lett. Pept. Sci.2, 225.
[7] M. Noda & M. Kiffe (1997) J. Peptide Res.50, 329.
 

联系

Replaces: 04-12-1103
 

分析说明

Colour (visual): white to off white
Appearance of substance (visual): powder
Colour index (0,5 M in DMF): ≤ 150 Hazen
Identity (IR): passes test
Enantiomeric purity: ≥ 99.7 % (a/a)
Purity (HPLC): ≥ 97.5 % (a/a)
Fmoc-ß-Ala-OH (HPLC): ≤ 0.3 % (a/a)
Fmoc-ß-Ala-Trp (Boc)-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Trp(Boc)-Trp(Boc)-OH (HPLC): ≤ 0.1 % (a/a)
Fmoc-Trp-OH (HPLC): ≤ 1.0 % (a/a)
Assay free amino acid (HPLC): ≤ 0.2 %
Solubility (25 mmole in 50 ml DMF): clear soluble
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 2.0 %
Ethyl acetate (HS-GC): ≤ 2.5 %
Acetate (IC): ≤ 0.10 %

To see the solvent systems used for TLC of Novabiochem® products please click here.
 

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
 
 

属性

质量水平

产品线

Novabiochem®

检测方案

≥90.0% (acidimetric)
≥97.5% (HPLC)
≥98% (TLC)

形式

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

官能团

Boc
Fmoc

储存温度

15-25°C

InChI

1S/C31H30N2O6/c1-31(2,3)39-30(37)33-17-19(20-10-8-9-15-27(20)33)16-26(28(34)35)32-29(36)38-18-25-23-13-6-4-11-21(23)22-12-5-7-14-24(22)25/h4-15,17,25-26H,16,18H2,1-3H3,(H,32,36)(H,34,35)/t26-/m0/s1

InChI key

ADOHASQZJSJZBT-SANMLTNESA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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