腺苷-5'-二磷酸钠盐，Adenosine 5′-diphosphate sodium salt [ADP]；bacterial, ≥95% (HPLC)

图片 腺苷-5'-二磷酸钠盐，Adenosine 5′-diphosphate sodium salt [ADP]；bacterial, ≥95% (HPLC)
5'二磷酸腺苷钠盐；Empirical Formula (Hill Notation): C10H15N5O10P2 CAS号: 20398-34-9 分子量: 427.20 eCl@ss: 32160414 PubChem化学物质编号: 24890690
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: A2754
CAS号: 20398-34-9
MDL号: MFCD00065470
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说明

腺苷5′-二磷酸（ADP）是一种腺嘌呤核苷酸，通过FOF1-ATP合酶转化为ATP参与能量储存和核酸代谢。ADP也可以通过腺苷酸激酶催化的腺苷酸单磷酸（AMP）反应获得。ADP是一种血小板激动剂，由血小板致密颗粒分泌。它通过与ADP受体P2Y1和P2Y12的相互作用促进血小板活化。当ADP通过外体ADP酶转化为腺苷时，血小板活化通过腺苷受体受到抑制。

一般描述

Adenosine 5′-diphosphate (ADP) is an adenine nucleotide involved in energy storage and nucleic acid metabolism via its conversion into ATP by FOF1-ATP synthases. ADP can also be obtained by adenylate monophosphate (AMP) reaction catalyzed by adenylate kinase. ADP is a platelet agonist that is secreted from platelet dense granules. It promotes platelet activation through its interaction with ADP receptors P2Y1 and P2Y12. Upon conversion of ADP to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.
 

应用

Adenosine 5′-diphosphate sodium salt has been used:
  • as a positive control of platelet aggregation to analyze antiplatelet activity of purified disintegrin byaggregometery
  • in the preparation of stock solution for a mito stress test
  • as a positive control in flow cytometry analysis to study the effect of pentameric C-reactive protein (pCRP) and monomeric CRP (mCRP) on the CD62p (P-selectin) expression of platelets

 

属性

生物来源

bacterial

质量水平

300

测定

≥95% (HPLC)

形式

powder

储存温度

−20°C

SMILES string

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O

InChI

1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

InChI key

XTWYTFMLZFPYCI-KQYNXXCUSA-N

Gene Information

human ... HSP90AA1(3320) , P2RY1(5028)

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

nwg

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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