紫铆因，Butein；≥98%

图片 紫铆因，Butein；≥98%
别名：布坦；1-（2,4-二羟基苯基）-3-（3,4-二羟基苯基）-2-丙烯-1-酮，2'，3,4,4'-四羟基查尔酮；1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one, 2′,3,4,4′-Tetrahydroxychalcone

Empirical Formula (Hill Notation): C15H12O5 CAS号: 487-52-5 分子量: 272.25 EC 号: 207-659-5 MDL编号: MFCD00017300 PubChem化学物质编号: 24891611 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: B178
CAS号: 487-52-5
MDL号: MFCD00017300
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¥3,350.00

说明

紫铆因（2′,3,4,4′-四羟基查耳酮）是一种查耳酮和类黄酮，在植物中产生。它是一种植物多酚和生物活性成分，从黄檀、卡拉加纳朱巴塔和罗氏黄檀的心材以及腰果的茎皮中提取。

紫铆因表现出几种药理活性，如抗氧化和抗炎活性。它刺激人宫颈癌细胞的凋亡细胞死亡。它对慢性疾病具有治疗潜力，包括肝结核、肥胖、糖尿病和高血压。布坦可以抑制膀胱，乳腺癌和胰腺癌细胞的迁移和侵袭。
抑制EGFR和Src酪氨酸激酶活性;抑制 cAMP 依赖性 PDE-IV。诱导B16黑色素瘤细胞和HL-60人白血病细胞凋亡。

一般描述

Butein (2′,3,4,4′-tetrahydroxychalcone) is a chalcone and a flavonoid, that is produced in plants. It is a plant polyphenol and a bioactive constituent, that is extracted from the heartwood of Dalbergia odorifera, Caragana jubata and Rhus verniciflua stokes, and the stem bark of cashews (Semecarpus anacardium).[1]
 

生化/生理作用

Butein exhibit several pharmacological activities, such as anti-oxidant and anti-inflammatory activity. It stimulates apoptotic cell death of human cervical cancer cells. It has therapeutic potentials for chronic diseases, including liver tuberculosis, obesity, diabetes and hypertension. Butein can repress migration and invasion of bladder, breast and pancreatic cancer cells.[1]
Inhibits EGFR and Src tyrosine kinase activities; inhibits cAMP-dependent PDE-IV. Induces apoptosis in B16 melanoma cells and HL-60 human leukemia cells.
 

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 

注意

Photosensitive
 
 

属性

形式

solid

质量水平

100

颜色

yellow

溶解性

DMSO: >50 mg/mL
H2O: insoluble

SMILES string

OC1=CC(O)=C(C(/C=C/C2=CC(O)=C(O)C=C2)=O)C=C1

InChI

1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+

InChI key

AYMYWHCQALZEGT-ORCRQEGFSA-N

Gene Information

rat ... Alox5(25290)

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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