穗花杉双黄酮，Amentoflavone；≥98.0% (HPLC)

图片 穗花杉双黄酮，Amentoflavone；≥98.0% (HPLC)
别名：阿曼托黄酮；8-(5-(5,7-二羟基-4-氧代-4H-苯并吡喃-2-基)-2-羟基苯基)-5,7-二羟基-2-(4-羟基苯基)-4H-苯并吡喃-4-酮；Didemethyl-ginkgetin, I3′,II8-Biapigenin, Tridemethylsciadopitysin

Empirical Formula (Hill Notation): C30H18O10 CAS号: 1617-53-4 分子量: 538.46 Beilstein: 380244 MDL编号: MFCD00017470 PubChem化学物质编号: 57650005 NACRES: NA.47
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: 40584
CAS号: 1617-53-4
MDL号: MFCD00017470
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¥1,100.87

说明

一般描述

Amentoflavone is a naturally occurring polyphenolic biflavonoid found in many plants. Structurally, it has an apigenin dimer which is linked by a C3′-C8′′ covalent bond.
 

应用

Amentoflavone has been used:
  • as a chemical inhibitor to determine the selective attenuation of p-Cresol glucuronidation in HepaRG cells
  • as a reference standard for qualitative and quantitative analyses of phenolic compounds of Juniperus foetidissima Willd. and Juniperus sabina L. using reverse phase- high-performance liquid chromatography- diode array detector (RP-HPLC-DAD)
  • as a reference standard to analyze and standardize the methanol extract process of Juniperus drupacea Labill. phenolic compounds using reverse phase- high-performance liquid chromatography - diode array detector (RP-HPLC-DAD)

生化/生理作用

Amentoflavone has various pharmacological properties such as antioxidant, anti-diabetic, anti-tumor, anti-senescence, neuroprotective, and cardioprotective activities.
Biflavonoid with anti-inflammatory, anti-viral and cancer chemopreventive activity. It inhibits vascularization of tumors by blocking the activity of angiogenic VEGFs. Blocks the induction of COX-2 and up-regulates PPAR-γ. It is a negative modulator of the GABAA receptor at the benzodiazepine binding site.
 
 

属性

质量水平

100

测定

≥98.0% (HPLC)

形式

solid

储存温度

2-8°C

SMILES string

Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)c(c3O2)-c4cc(ccc4O)C5=CC(=O)c6c(O)cc(O)cc6O5

InChI

1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H

InChI key

YUSWMAULDXZHPY-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554)

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 30 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 30
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