磺基舒林，Sulindac sulfone；≥94% (HPLC), (solid or powder)

图片 磺基舒林，Sulindac sulfone；≥94% (HPLC), (solid or powder)
别名：(Z)-5-氟-2-甲基-1- [对-(甲基磺酰基)亚苄基]茚-3-乙酸；舒林酸砜；(Z)-5-Fluoro-2-methyl-1-[p-(methylsulfonyl)benzylidene]indene-3-acetic acid

Empirical Formula (Hill Notation): C20H17FO4S CAS号: 59864-04-9 分子量: 372.41 MDL编号: MFCD01317811 PubChem化学物质编号: 24278693 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: S1438
CAS号: 59864-04-9
MDL号: MFCD01317811
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¥1,377.55

说明

应用

Human endothelial cells, HMEC-1 were treated with Sulindac sulfone and the effect on cell survival was studied by MTT assay.[1]
 

生化/生理作用

Sulindac sulfone is non-steroidal anti-inflammatory drug and an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells1,2 and reduces tumor burden in adenomatous polyposis patients.3
Metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. Inhibits the development and induces regression of premalignant adenomatous polyps.
 

特点和优势

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

制备说明

Sulindac sulfone yields clear, light yellow to dark yellow solution in acetone at 50 mg/ml.
 
 

属性

质量水平

100

测定

≥94% (HPLC)

形式

(solid or powder)

颜色

Light Yellow to Dark Yellow

溶解性

DMSO: >25 mg/mL
ethanol: 3 mg/mL (warm)
acetone: 5 mg (plus 0.1 ml)

创始人

Merck & Co., Inc., Kenilworth, NJ, U.S.

SMILES string

CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C\c3ccc(cc3)S(C)(=O)=O

InChI

1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9+

InChI key

MVGSNCBCUWPVDA-RQZCQDPDSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
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