盐酸雷洛昔芬，Raloxifene hydrochloride；≥98%

图片 盐酸雷洛昔芬，Raloxifene hydrochloride；≥98%
别名：雷洛昔芬盐酸盐；盐酸克昔芬；(6-羟基-2-(4-羟基苯基)苯并[b]噻吩-3-基)-(4-(2-(哌啶-1-基)乙氧基)苯基)甲酮盐酸盐；Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride

Empirical Formula (Hill Notation): C28H27NO4S · HCl CAS号: 82640-04-8 分子量: 510.04 MDL编号: MFCD01938233 PubChem化学物质编号: 24278673 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: R1402
CAS号: 82640-04-8
MDL号: MFCD01938233
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¥3,350.00

说明

应用

Raloxifene hydrochloride has been used:
  • as a competitive inhibitors for estrogen receptor α in breast cancer cells[1]
  • as an anti-resorptive agents to test its effect on improving bone mineral density (BMD) in six-month-old female ovariectomized rats[2]
  • to test effect on viability of esophageal adenocarcinoma cells[3]

生化/生理作用

Raloxifene is benzothiophene compound and is used in treating postmenopausal osteoporosis[4] It comparatively induces lesser risk in developing thromboembolic events and cataracts compared to tamoxifen.[5] Raloxifene also interacts with estrogen receptors and plasma proteins.[5]
Raloxifene is a selective estrogen receptor modulator (SERM); acts as an anti-estrogen in both breast and uterine tissue while being estrogenic in bone. May have efficacy against estrogen-sensitive cancers.
 

特点和优势

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

形式

solid

质量水平

100

颜色

light yellow

溶解性

DMSO: soluble 28 mg/mL
H2O: insoluble

创始人

Eli Lilly

SMILES string

Cl[H].Oc1ccc(cc1)-c2sc3cc(O)ccc3c2C(=O)c4ccc(OCCN5CCCCC5)cc4

InChI

1S/C28H27NO4S.ClH/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29;/h4-13,18,30-31H,1-3,14-17H2;1H

InChI key

BKXVVCILCIUCLG-UHFFFAOYSA-N

Gene Information

human ... ESR2(2100)

 

安全信息

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H351 - H361d

危险分类

Carc. 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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