盐酸硫胺 [维生素B1盐酸盐]，Thiamine hydrochloride；BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99.0%

图片 盐酸硫胺 [维生素B1盐酸盐]，Thiamine hydrochloride；BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99.0%
别名：硫胺盐酸盐；维生素B1盐酸盐；维他命B1盐酸盐；硫胺素；VB1；抗神经炎素 ；Aneurine hydrochloride；Vitamin B1 hydrochloride

Empirical Formula (Hill Notation): C12H17ClN4OS · HCl CAS号: 67-03-8 分子量: 337.27 Beilstein: 3851771 EC 号: 200-641-8 MDL编号: MFCD00012780 eCl@ss: 34058006 PubChem化学物质编号: 24899952 NACRES: NA.75
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: T1270
CAS号: 67-03-8
MDL号: MFCD00012780
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √
¥761.64

说明

硫胺素或维生素B1是带正电的所有组织的必需成分。它在骨骼肌、肝脏、肾脏、心脏和大脑中的含量较高。硫胺素由一个嘧啶环通过亚甲基桥连接到噻唑环上。
硫胺素在进入细胞膜后被硫胺素二磷酸激酶转化为硫胺素。二磷酸硫胺素是一种活性辅因子，对柠檬酸循环、糖酵解途径、支链氨基酸降解和磷酸戊糖途径中涉及的许多酶的机制至关重要。硫胺素参与将食物转化为中枢和外周神经系统功能所需的能量。这种维生素水平较低与谵妄、韦尼克脑病和韦尼克-科尔萨科夫综合征有关。盐酸硫胺素需要支持培养细胞中的能量代谢和氨基酸合成。它存在于许多经典和无血清配方中。

一般描述

Thiamine or Vitamin B1 is a positively charged and essential constituent for all tissues. It is present at higher levels in skeletal muscles, liver, kidney, heart, and brain. Thiamine is composed of a pyrimidine ring linked to a thiazole ring via a methylene bridge.
 

应用

Thiamine hydrochloride has been used as a component:
  • of the vitamin-concentrated stock solution for the preparation of Hv-Ca medium for culturing Haloferax volcanii
  • of the tris-acetate-phosphate (TAP) medium for culturing Chlamydomonas nivalis
  • of modified Bold 3N medium for culturing Chlorella minutissima

生化/生理作用

Thiamine is converted to thiamine diphosphate post-movement into the cellular membranes by thiamine diphosphokinase. Thiamine diphosphate, an active cofactor is essential for the mechanism of many enzymes involved in the citric acid cycle, the glycolytic pathway, the degradation of branched-chain amino acids, and the pentose phosphate pathway. Thiamine is involved in converting food into energy required for functioning the central and peripheral nervous systems. Lower levels of this vitamin are associated with delirium, Wernicke′s encephalopathy, and Wernicke-Korsakoff syndrome. Thiamine hydrochloride is required to support energy metabolism and amino acid synthesis in cultured cells. It is present in many classical and serum-free formulations.
 
 

属性

生物来源

synthetic (organic)

质量水平

200

产品线

BioReagent

测定

≥99.0% (HPLC)

形式

powder

分子量

Mw 337.27 g/mol

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

颜色

white

mp

250 °C (dec.) (lit.)

溶解性

H2O: 50 mg/mL, clear, colorless

application(s)

agriculture

SMILES string

CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]

InChI

1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1

InChI key

DPJRMOMPQZCRJU-UHFFFAOYSA-M

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H319

危险分类

Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 1

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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