特比萘芬盐酸盐 [盐酸特比萘芬]，Terbinafine hydrochloride；Pharmaceutical Secondary Standard; Certified Reference Material

图片 特比萘芬盐酸盐 [盐酸特比萘芬]，Terbinafine hydrochloride；Pharmaceutical Secondary Standard; Certified Reference Material
别名：特比萘芬盐酸盐标准品；盐酸特比萘芬标准品；反式-N-(6,6-二甲基-2-庚-4-基)-N-甲基-1-萘甲胺盐酸盐；trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine hydrochloride

Empirical Formula (Hill Notation): C21H25N · HCl CAS号: 78628-80-5 分子量: 327.89 MDL编号: MFCD00145430 PubChem化学物质编号: 329823287 NACRES: NA.24
制造商品牌: 色谱科 Supelco , 西格玛 Sigma-Aldrich
货号（SKU）: PHR1298
CAS号: 78628-80-5
MDL号: MFCD00145430
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √
¥1,044.73

说明

用于质量控制的认证药品二级标准为制药实验室和制造商提供了药典一级标准的方便和经济的替代品。盐酸特比萘芬是一种抗真菌药物。它的作用方式包括抑制角鲨烯环氧化物酶，角鲨烯环氧化物酶是参与麦角甾醇生物合成的真菌细胞系统的重要组成部分。
盐酸特比萘芬可用作通过紫外分光光度法和高效薄层色谱（HPTLC）测定药物剂型中分析物的药物参考标准。

一般描述

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. Terbinafine hydrochloride is an antifungal drug. Its mode of action involves the inhibition of squalene epoxidase enzyme, an essential component of fungal cell systems involved in ergosterol biosynthesis.
烯丙胺衍生物。
 

应用

Terbinafine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by UV spectrophotometry and high-performance thin layer chromatography (HPTLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
 

生化/生理作用

作用方式：抑制角鲨烯环氧酶，防止麦角甾醇的生物合成。
抗菌谱：抗真菌和抗真菌。抗皮肤细胞和一些酵母的杀真菌剂；抗真菌白色念珠菌。
 

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
 

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
 

附注

To see an example of a Certificate of Analysis for this material enter LRAC3257 in the slot below. This is an example certificate only and may not be the lot that you receive.
 
 

属性

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. Y0000535
traceable to USP 1643496

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

Cl[H].[H]\C(CN(C)Cc1cccc2ccccc12)=C(\[H])C#CC(C)(C)C

InChI

1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;

InChI key

BWMISRWJRUSYEX-SZKNIZGXSA-N

 

安全信息

象形图

Exclamation markEnvironment
GHS07,GHS09

警示用语：

Warning

危险分类

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 30 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 30
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