Application
一种TORC1/2抑制剂，IC50：1 nM。也是具有潜在抗肿瘤活性的raptor-mTOR(TOR复合体1或TORC1)和.or-mTOR(TOR复合体2或TORC2)的抑制剂。
Sapanisertib is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. TORC1/2 inhibitor INK128 binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers.
Sapanisertib是TORC1 / 2抑制剂，也是具有潜在抗肿瘤活性的raptor-mTOR（TOR复合物1或TORC1）和rictor-mTOR（TOR复合物2或TORC2）的口服生物利用抑制剂。 TORC1 / 2抑制剂INK128结合并抑制mTOR的TORC1和TORC2复合物，这可能导致肿瘤细胞凋亡和肿瘤细胞增殖减少。 TORC1和2在某些肿瘤中上调，并在PI3K / Akt / mTOR信号通路中起重要作用，而PI3K / Akt / mTOR信号通路在人类癌症中经常失调。
性质
| Iupac Name | 3-(2-amino-1,3-benzoxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Inchi Code | 1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19) |
| Inchi Key | GYLDXIAOMVERTK-UHFFFAOYSA-N |
安全信息
RIDADR NONH for all modes of transport
