毛地黄皂苷，Digitonin [Digitin]；~50% (TLC)

别名：Digitin；一种非离子洗涤剂；洋地黄皂苷；毛地黄皂甙；毛地黄叶苷；地芰脱皂苷

Empirical Formula (Hill Notation): C56H92O29 CAS号: 11024-24-1 分子量: 1229.31 Beilstein: 78654 EC 号: 234-255-6 MDL编号: MFCD00077729 PubChem化学物质编号: 24893949 NACRES: NA.25

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: D5628

CAS号: 11024-24-1

MDL号: MFCD00077729

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目录价.SKU-Variant

1g
5g [+¥12,547.97]

¥3,922.51

数量:

说明

一般描述

Digitonin是一种可协同增强癌细胞中植物次生代谢产物细胞毒性的生物去污剂和皂苷。 [1][2]

Digitonin, a non-ionic detergent, is obtained from foxglove. This saponin has a head-tail structure. Two galactose, two glucose, and a xylose are present on its bulky sugar headgroup.

应用

Digitonin已用于研究脂肽毒素是如何靶向生物膜的。 [3]

Digitonin has been used:

to incubate isolated mitochondria for removing the mitochondrial outer membrane for mitoplasts preparation
in the permeabilization of HeLa cells for in vitro import assay
as a component in HEPES-buffered saline (HBS) to permeate the cells and release the aequorins for fluorescence and bioluminescence imaging

生化/生理作用

Digitonin plays a key role in permeabilizing cell membranes. It also helps to solubilize membrane components. Digitonin specifically interacts with cholesterol in the membrane, resulting in pore formation. It helps to lyse eukaryotic cells but not bacterial membranes.

特点和优势

Can extract membrane proteins like supercomplexes from the mitochondrial inner membrane
Solubilizes 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) large unilamellar vesicles (LUVs) gradually at high temperature
Canorm micelles at a wide range of concentrations

属性

描述

non-ionic

质量水平

200

测定

~50% (TLC)

形式

powder

分子量

micellar avg mol wt 70,000

聚集数

CMC

<0.5 mM (20-25°C)

mp

230-240 °C (dec.) (lit.)

SMILES string

C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])[C@@H](O)[C@@]1([H])[C@@](CC[C@]5([H])[C@@]6(C[C@@H](O)[C@H](O[C@]([C@@H]([C@@H](O)[C@H]7O[C@@](O[C@H](CO)[C@@H](O)[C@@H]8O[C@@](OC[C@@H](O)[C@@H]9O)([H])[C@@H]9O)([H])[C@@H]8O[C@@](O[C@H](CO)[C@H

InChI

1S/C56H92O29/c1-19-7-10-56(75-17-19)20(2)31-45(85-56)37(67)32-22-6-5-21-11-26(24(61)12-55(21,4)23(22)8-9-54(31,32)3)76-50-42(72)39(69)44(30(16-60)80-50)81-53-48(47(36(66)29(15-59)79-53)83-49-40(70)33(63)25(62)18-74-49)84-52-43(73)46(35(65)28(14-58)78-52)82-51-41(71)38(68)34(64)27(13-57)77-51/h19-53,57-73H,5-18H2,1-4H3/t19-,20+,21+,22-,23+,24-,25-,26-,27-,28-,29-,30-,31+,32-,33+,34-,35+,36-,37+,38+,39-,40-,41-,42-,43-,44+,45-,46+,47+,48-,49+,50-,51+,52+,53+,54-,55+,56-/m1/s1

InChI key

UVYVLBIGDKGWPX-KUAJCENISA-N

安全信息

象形图

GHS06,GHS08

警示用语：

Danger

危险声明

H301 - H373

预防措施声明

P301 + P310 + P330 - P314

危险分类

Acute Tox. 3 Oral - STOT RE 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

商品规格

属性名称	属性值
储存温度 Storage temp.	常温阴凉避光
全球实时库存 Availability √	美国St. Louis ≥ 50 \| 欧洲Eur. ≥ 12 \| 東京Tokyo ≥ 20 \| 香港与北京 ≥ 50

商品标签 [tags]

毛地黄皂苷 (2)