普罗沙普肽Tx 14(A)三氟乙酸盐，Prosaptide Tx 14(A) trifluoroacetate salt；≥95% (HPLC)

图片 普罗沙普肽Tx 14(A)三氟乙酸盐，Prosaptide Tx 14(A) trifluoroacetate salt；≥95% (HPLC)
别名：GPR37和GPR37L1激动剂；H-Thr-D-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr-OH trifluoroacetate salt, Prosaptide trifluoroacetate salt, TX14(A) trifluoroacetate salt, TXLIDNNATEEILY (Modifications: Ala-2 = D-Ala) trifluoroacetate salt, TaLIDNNATEEILY trifluoroacetate salt

经验公式（希尔记法）: C69H110N16O26 · xC2HF3O2 CAS号: 196391-82-9 分子量: 1579.70 (free base basis)
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SML1417
CAS号: 196391-82-9
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说明

生化/生理作用

Prosaptide Tx 14(A) is a potent agonist of G protein-coupled receptors GPR37 (also known as Parkin-associated endothelin receptor-like receptor Pael-R) and GPR37L1. Prosaptide Tx 14(A) is the active fragment of prosaposin, a secreted neuroprotective and glioprotective factor. Prosaptide Tx 14(A) has EC50 values of 5 nM for GPR37L1 and 7 nM for GPR37, and has also been shown to have some GSK3 inhibitory properties. Prosaptide has been shown to improve nerve regeneration in diabetic rats, to reduce neuropathic pain, and to protect dopaminergic neurons in animal models of Parkinson disease.
 
 

属性

质量水平

100

检测方案

≥95% (HPLC)

形式

powder

颜色

white to off-white

运输

wet ice

储存温度

−20°C

InChI

1S/C69H110N16O26/c1-13-31(7)53(66(107)80-41(23-29(3)4)61(102)82-46(69(110)111)25-37-15-17-38(88)18-16-37)83-59(100)40(20-22-50(93)94)75-58(99)39(19-21-49(91)92)76-68(109)55(36(12)87)85-57(98)34(10)73-60(101)43(26-47(70)89)78-62(103)44(27-48(71)90)79-63(104)45(28-51(95)96)81-67(108)54(32(8)14-2)84-64(105)42(24-30(5)6)77-56(97)33(9)74-65(106)52(72)35(11)86/h15-18,29-36,39-46,52-55,86-88H,13-14,19-28,72H2,1-12H3,(H2,70,89)(H2,71,90)(H,73,101)(H,74,106)(H,75,99)(H,76,109)(H,77,97)(H,78,103)(H,79,104)(H,80,107)(H,81,108)(H,82,102)(H,83,100)(H,84,105)(H,85,98)(H,91,92)(H,93,94)(H,95,96)(H,110,111)/t31-,32-,33+,34-,35+,36+,39-,40-,41-,42-,43-,44-,45-,46-,52-,53-,54-,55-/m0/s1

InChI key

SMUKRAODILXPSW-SRWCCNGVSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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