General description
一种BTK抑制剂。
Olmutinib is a potent small molecule inhibitor of Bruton's tyrosine kinase (BTK). BTK is a member of the Tec family of non-receptor protein tyrosine kinases. BTK is mostly expressed in hematopoietic cells such as B cells, mast cells and macrophages. BTK plays key roles in multiple cell signaling pathways including B-Cell Receptor (BCR) and Fc receptor (FcR) signaling cascades and is an essential mediator not only in B-cell dependent but also in myeloid cell dependent inflammatory arthritis. HM71224 has been selected as a novel therapeutic agent for the treatment of autoimmune diseases such as RA。
Olmutinib是Bruton酪氨酸激酶（BTK）的有效小分子抑制剂。 BTK是非受体蛋白酪氨酸激酶Tec家族的成员。 BTK主要在造血细胞如B细胞，肥大细胞和巨噬细胞中表达。 BTK在包括B细胞受体（BCR）和Fc受体（FcR）信号级联在内的多种细胞信号通路中起着关键作用，不仅在依赖B细胞而且在依赖髓样细胞的炎性关节炎中也是必不可少的介质。 HM71224已被选为治疗自身免疫性疾病（例如RA）的新型治疗剂。
Properties
| Iupac Name： | N-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide |
| Inchi Code | 1S/C26H26N6O2S/c1-3-23(33)27-19-5-4-6-21(17-19)34-25-24-22(11-16-35-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30) |
| Inchi Key | FDMQDKQUTRLUBU-UHFFFAOYSA-N |
安全信息
