头孢拉啶 [头孢拉定]，Cephradine；≥90.0% (Cephradine, HPLC)

图片 头孢拉啶 [头孢拉定]，Cephradine；≥90.0% (Cephradine, HPLC)
别名：Cefradin；头孢拉丁；头孢握定；头孢雷定；己环胺菌素；头孢环己烯；环己烯胺头孢菌素；环烯头孢菌素；Cefradin，CEPHRADINE COMPACTED; CEPHRADINE MICRONISED POWDER; Cephradine; Anspor; Velosef; (6r-(6alpha,7))-((amino-1,4-cyclohexadien-1-ylacetyl)amino)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (7R)-7-{[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Empirical Formula (Hill Notation): C16H19N3O4S CAS号: 38821-53-3 分子量: 349.40 MDL编号: MFCD00865048 PubChem化学物质编号: 24278342 NACRES: NA.85
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: C8395
CAS号: 38821-53-3
MDL号: MFCD00865048
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说明

化学结构：ß-内酰胺
头孢拉定用于研究PBP3和其他青霉素结合蛋白（PBPs）的表达、结合和抑制对细菌细胞壁粘肽合成的影响。
头孢拉定是一种半合成头孢菌素，它通过与某些青霉素结合蛋白（PBPs）结合来抑制细菌细胞壁合成的最后阶段，如PBP3，从而导致细胞裂解。细胞裂解由细菌细胞壁自溶酶介导。它对革兰氏阳性和革兰氏阴性细菌有效。头孢拉定也可能干扰自溶素抑制剂。

一般描述

Chemical structure: ß-lactam
 

应用

Cefradin was used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.
 

生化/生理作用

Cefradin is a semi-synthetic cephalosporin that inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins (PBPs), such as PBP3, which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. It is effective against Gram-positive and Gram-negative bacteria. Cefradin may also interfere with autolysin inhibitors.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place.
 
 

属性

质量水平

200

测定

≥90.0% (Cephradine, HPLC)

形式

powder

溶解性

ethanol: practically insoluble 96%
hexane: practically insoluble
water: slightly soluble

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

cell wall synthesis | interferes

储存温度

2-8°C

SMILES string

[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C3=CCC=CC3)C(O)=O

InChI

1S/C16H19N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1

InChI key

RDLPVSKMFDYCOR-UEKVPHQBSA-N

 

安全信息

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Danger

危险分类

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 30 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 30
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