大鼠IgG，IgG from rat serum；reagent grade, ≥95% (SDS-PAGE), essentially salt-free, lyophilized powder

General description

IgG antibody provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections^[4] Rat IgG is purified from pooled normal rat serum by fractionation and ion-exchange chromatography.

IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids, Immunoglobins have two heavy (H) and two light (L) chains, linked by disulphide linkages. Each light chain comprises one variable N-terminal region and a constant C-terminal region. Heavy chain has one variable N-terminal region and three or four constant (CH1-CH4) C-terminal region.^[5] The four classes of IgG can be IgG1, IgG2, IgG3, and IgG4.^[6]

Application

IgG from rat serum has been used:
•  in immunolabeling^[8]
• in flow cytometry^[9]
• in enzyme linked immunosorbent assay^[10]
• as a control in neutrophil depletion assay
使用大鼠血清中的IgG作为：
•免疫标记
•流式细胞仪
•在酶联免疫吸附测定中
•作为中性粒细胞耗竭试验的对照
IgG抗体具有巨大的治疗潜力，其片段可结晶（Fc）区有助于治疗性抗体的发展。

包装

10, 50, 100 mg in poly bottle

Biochem/physiol Actions

IgG antibody have enormous therapeutic potential and its fragment crystallizable (Fc) region contributes for the development of therapeutic antibody.^[7]

Disclaimer

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性质

安全信息