去乙基氯喹，Desethylchloroquine；≥95% (HPLC)

图片 去乙基氯喹，Desethylchloroquine；≥95% (HPLC)
别名：4-[[1-甲基-4-((乙基氨基)丁基]氨基)]-7-氯喹啉；N-去乙基氯喹；7-氯-4-{[4-(乙基氨基)-1-甲基丁基]氨基}喹啉；7-氯-4-(4-N-乙基氨基-1-甲基丁基氨基)喹啉；单去乙基氯喹；N-去乙基氯喹；单去乙基氯喹；4-[[1-Methyl-4-((ethylamino)butyl]amino)]-7-chloroquinoline, N-Desethyl chloroquine, N4-(7-Chloro-4-quinolinyl)-N1-ethyl-1,4-pentanediamine, 7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline, 7-Chloro-4-(4-N-ethylamino-1-methylbutylamino)quinoline, Monodesethylchloroqu​ine, N-Desethylchloroquine, Monodeethylchloroquine

Empirical Formula (Hill Notation): C16H22ClN3 CAS号: 1476-52-4 分子量: 291.82 MDL编号: MFCD00871808
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SMB00963
CAS号: 1476-52-4
MDL号: MFCD00871808
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¥4,144.57

说明

去乙基氯喹是羟氯喹和氯喹的代谢物。 羟氯喹和氯喹具有抗疟疾特性，可用作类风湿性关节炎 (RA)、系统性红斑狼疮 (SLE) 和其他炎症性风湿性疾病的治疗剂。 由于他们对 COVID-19 患者的活动，他们也受到关注，这种疾病是由 SARS-CoV-2 病毒引起的。 羟氯喹和氯喹会干扰溶酶体活性和自噬，与膜稳定性相互作用并改变信号通路和转录活性，从而调节细胞因子的产生。 它们的作用方式仍在出现，它们的新陈代谢引起了人们的极大兴趣。

一般描述

Desethylchloroquine is a metabolite of hydroxychloroquine and chloroquine. Hydroxychloroquine and chloroquine have antimalarial properties and are used as a therapeutic for rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. They have also been in the spotlight due to their activity on patients with COVID-19, the disease caused by the SARS-CoV-2 virus. Hydroxychloroquine and chloroquine interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production. Their mode of action is still emerging and their metabolism is of great interest.
 

应用

Application: Metabolomics research
 
 

属性

质量水平

200

生物来源

synthetic

等级

research grade

测定

≥95% (HPLC)

形式

powder or crystals

technique(s)

HPLC: suitable

颜色

white to off-white

运输

wet ice

储存温度

2-8°C

SMILES string

ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2

InChI

1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)

InChI key

MCYUUUTUAAGOOT-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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