刺芒柄花素，Formononetin；≥99.0% (TLC)

图片 刺芒柄花素，Formononetin；≥99.0% (TLC)
别名：7-羟基-3-（4-甲氧基苯基）-4-H-1-苯并吡喃-4-酮, 7-羟基-3-（4-甲氧基苯基）色酮, 7-羟基-4′-甲氧基异黄酮, 刺芒柄花素, 刺芒柄花醇, 大豆苷元-4′-甲基醚, 鹰嘴豆素B；7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one, 7-Hydroxy-3-(4-methoxyphenyl)chromone, 7-Hydroxy-4′-methoxyisoflavone, Biochanin B, Daidzein 4′-methyl ether, Formonetin, Formononetol

Empirical Formula (Hill Notation): C16H12O4 CAS号: 485-72-3 分子量: 268.26 Beilstein: 237979 EC 号: 207-623-9 MDL编号: MFCD00016948 PubChem化学物质编号: 57651100 NACRES: NA.47
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: 47752
CAS号: 485-72-3
MDL号: MFCD00016948
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¥1,230.38

说明

一般描述

Formononetin is an O-methylated isoflavone[1], a phytoestrogen.[2] It can be found in many legumes, different species of clovers primarily in Trifolium pratense L. (red clovers), and one of the main flavonoids found in Astragalus membranaceus (Huangqi).[1]
 

应用

Formononetin has been used:
  • as a reference standard to study export of multiple metabolites from Crocus sativus stigma extracts using liquid chromatography-photodiode array-high resolution mass spectrometry (LC-PDA-HRMS)[3]
  • as phytoestrogen-mimetic isoflavones to test its antioxidant effects in a biomimetic environment using chemiluminescence method[4]
  • as an authentic standard to test the isoflavones content level in both wild type and transgenic Medicago truncatula plant using high-performance liquid chromatography (HPLC)[5]
  • to test its effects as a potential Aryl hydrocarbon receptor (AhR)-agonist on the restoration of skin barrier proteins for Atopic dermatitis (AD) treatment using different keratinocyte cell lines and human skin equivalent (HSE) model[6]

生化/生理作用

异黄酮在红三叶草中发现。可通过（至少部分通过）诱导肠粘膜中滋养体的分离，有效对抗 贾第鞭毛虫 的感染。
Formononetin elicits antioxidant, anti-inflammatory, anti-hyperlipidemic, and cardioprotective effects.[7] It displays antidiabetic properties known to be effective against diabetic nephropathy in type 2 diabetes mellitus.[7] Formononetin is a well-known anti-cancer and chemotherapeutic agent that is used in cancer therapy.[1] It also displays antimicrobial, neuroprotective, and anti-hypertensive properties.[2]
 
 

属性

质量水平

100

测定

≥99.0% (TLC)

形式

solid

mp

257-261 °C

SMILES string

COc1ccc(cc1)C2=COc3cc(O)ccc3C2=O

InChI

1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3

InChI key

HKQYGTCOTHHOMP-UHFFFAOYSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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