| Catalogue Number | A190245 |
| Chemical Name | Aconine |
| Synonyms | 11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine; Aconitane-3,8,13,14,15-pentol deriv.; Jesaconine |
| CAS Number | 509-20-6 |
| Molecular Formula | C25H41NO9 |
| Appearance | Off-White to Pale Yellow Solid |
| Melting Point | >124°C (dec.) |
| Molecular Weight | 499.59 |
| Storage | -20°C Freezer |
| Solubility | Chloroform (Slightly), DMSO (Slightly) |
| Category | Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; |
| Applications | Aconine is a derivative of Aconitine (A189875), a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. |
| References | Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010), |
