PNU-120596，≥98% (HPLC)

图片 PNU-120596，≥98% (HPLC)
别名：PNU120596；N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea, NSC 216666

Empirical Formula (Hill Notation): C13H14ClN3O4 CAS号: 501925-31-1 分子量: 311.72 MDL编号: MFCD00095313 PubChem化学物质编号: 329819995 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: P0043
CAS号: 501925-31-1
MDL号: MFCD00095313
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¥1,175.20

说明

生化/生理作用

An allosteric modulator of α7 nicotinic receptors, N-(5-chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholinePNU-120596 is a positive allosteric modulator selective for the α7 nicotinic acetylcholine receptor. PNU-120596 produces no detectable change in currents mediated by α4β2, α3β4, α9α10 nAChRs. It increases channel mean open time, but does not affect ion selectivity. It does not bind at the agonist binding site, but induces conformational changes similar to the natural effector.
 

特点和优势

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

颜色

white to off-white

溶解性

DMSO: >10 mg/mL

创始人

Pfizer

储存温度

room temp

SMILES string

COc1cc(OC)c(NC(=O)Nc2cc(C)on2)cc1Cl

InChI

1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)

InChI key

CEIIEALEIHQDBX-UHFFFAOYSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
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