CP-101606，≥98% (HPLC)

别名：CP101606；Traxoprodil；NMDA拮抗剂；(1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol；(1s,2s)-1-[4-羟苯基]-2-(4-羟基-4-苯哌啶基)-1-丙醇

Empirical Formula (Hill Notation): C20H25NO3 CAS号: 134234-12-1 分子量: 327.42 MDL编号: MFCD00926469 PubChem化学物质编号: 329825120 NACRES: NA.77

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: SML0053

CAS号: 134234-12-1

MDL号: MFCD00926469

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目录价.SKU-Variant

5mg
25mg [+¥3,582.10]
100mg [+¥11,125.06]

¥1,175.20

数量:

说明

一般描述

CP-101,606 (Traxoprodil) is a substituted 4-phenylpiperidine and is localized in the fore brain neurons.[1][2]

应用

CP-101,606 has been used as a N-methyl-D-aspartate (NMDA) receptor antagonist to study its role in recovery of spinal cord injuries.[3]

生化/生理作用

CP-101,606 (Traxoprodil) plays a role in inhibiting glutamate-induced death in rats. It may exhibit therapeutic effects against human ischemia and neurodegenerative disorders.[1] Traxoprodil is metabolized by cytochrome P450 (CYP) 2D6.[2]

Traxoprodil (CP-101,606) is a potent noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, selective for the NR2B subunit. It has been shown to be neuroprotective in animal models of brain injury and stroke.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

旋光性

[α]/D +50 to +60° (c=1, MeOH)

颜色

white to tan

溶解性

DMSO: ≥35 mg/mL

创始人

Pfizer

储存温度

2-8°C

SMILES string

C[C@@H]([C@@H](O)c1ccc(O)cc1)N2CCC(O)(CC2)c3ccccc3

InChI

1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1

InChI key

QEMSVZNTSXPFJA-HNAYVOBHSA-N

Gene Information

human ... GRIN1(2902) , GRIN2B(2904)

安全信息

储存分类代码

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 20 \| 欧洲Eur. ≥ 16 \| 東京Tokyo ≥ 5 \| 香港与北京 ≥ 20

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