西诺沙星,Cinoxacin;powder or crystals, 97.0-102.0%

别名:1-乙基-1,4-二氢-4-氧代-[1,3]二氧代-[4,5-g]齐诺啉-3-羧酸;1-Ethyl-1,4-dihydro-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid Empirical Formula (Hill Notation): C12H10N2O5 CAS号: 28657-80-9 分子量: 262.22 EC 号: 249-133-8 MDL编号: MFCD00056776 PubChem化学物质编号: 24278343 NACRES: NA.85
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): C8645
CAS号: 28657-80-9
MDL号: MFCD00056776
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √
¥1,209.89

说明

化学结构:喹诺酮类
西诺沙星用于研究大鼠肾脏有机阴离子转运蛋白1(OAT1),用于研究耐氟喹诺酮的化脓性链球菌。
西诺沙星是一种合成抗菌剂,通过紧密的DNA结合抑制DNA回旋酶和拓扑异构酶IV(topo IV),从而干扰DNA复制。西诺沙星的作用机制与萘啶酸相当。西诺沙星对革兰氏阴性菌有效,常用于治疗大肠杆菌引起的尿路感染。大肠杆菌、奇异变形杆菌、普通变形杆菌和克雷伯菌属。

一般描述

Chemical structure: quinolone
 

应用

Cinoxacin was used to study the rat renal organic anion transporter 1 (OAT1). It is used to study fluoroquinolone-resistant Streptococcus pyogenes.
 

生化/生理作用

Cinoxacin is a synthetic antimicrobial agent that interferes with DNA replication by inhibiting DNA gyrase and topoisomerase IV (topo IV) through tight DNA binding. The mechanism of action of cinoxacin is comparable to nalidixic acid. Cinoxacin is effective against Gram-negative bacteria and is often used to treat urinary tract infections caused by E. coliProteus mirabilisProteus vulgaris and Klebsiella sp.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C8645.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
 
 

属性

形式

powder or crystals

质量水平

200

抗生素抗菌谱

Gram-negative bacteria

作用机制

DNA synthesis | interferes
enzyme | inhibits

SMILES string

CCN1N=C(C(O)=O)C(=O)c2cc3OCOc3cc12

InChI

1S/C12H10N2O5/c1-2-14-7-4-9-8(18-5-19-9)3-6(7)11(15)10(13-14)12(16)17/h3-4H,2,5H2,1H3,(H,16,17)

InChI key

VDUWPHTZYNWKRN-UHFFFAOYSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50