唑尼泊利特盐酸盐水合物，Zoniporide hydrochloride hydrate；≥98% (HPLC)

图片 唑尼泊利特盐酸盐水合物，Zoniporide hydrochloride hydrate；≥98% (HPLC)
别名：[1-(喹啉-5-基)-5-环丙基-1H-吡唑-4-甲酰基]胍盐酸盐；N-(氨基亚氨基甲基)-5-环丙基-1-(5-喹啉基)-1H-吡唑-4-甲酰胺盐酸盐水合物；N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide hydrochloride hydrate

Empirical Formula (Hill Notation): C17H16N6O · xHCl · yH2O CAS号: 241800-98-6 (free base) 分子量: 320.35 (anhydrous free base basis) MDL编号: MFCD04113213 PubChem化学物质编号: 329825138 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SML0076
CAS号: 241800-98-6
MDL号: MFCD04113213
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说明

应用

Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models.[1] It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication.[2]
Zoniporide hydrochloride hydrate may be used in Na+/H+-mediated cell signaling studies.
 

生化/生理作用

Zoniporide is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1). IC50 = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na+ update with IC50 of 14 nM.
Zoniporide, a selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE-1) has cardioprotective effects against myocardial injuries and ischemic insults.[3] It inhibits the swelling human platelets and attenuates cardiac contractile dysfunction in rats.[4] Zoniporide might have neurotoxic effects as it causes peripheral sensory axonopathy.[5]
 

特点和优势

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

颜色

white to tan

溶解性

H2O: 2 mg/mL, clear (warmed)

创始人

Pfizer

储存温度

2-8°C

SMILES string

O.Cl.NC(=N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C4CC4

InChI

1S/C17H16N6O.ClH.H2O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H;1H2

InChI key

UCIJUEGJEFJRMP-UHFFFAOYSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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